20%+

avg. body weight reduction

46 lbs

avg. lost in 72-week trial

2×

receptor targets vs. single agonist

1×

weekly injection, self-administered

U.S. licensed pharmacy HIPAA compliant FSA / HSA eligible

Dual GLP-1/GIP Agonist

GLP-1/GIP+ Therapy

Dual-receptor action: targets both GLP-1 and GIP pathways — delivering more pronounced weight loss than single-agonist therapy alone.

In stock Bulk order available

Starting at

^$194 $495

per monthly dose · all-inclusive

Doctor consult, medication & shipping all included

Receptor activity comparison

GLP-1 (Tirz)

GIP (Tirz)

GLP-1 (Sema)

This treatment activates both GLP-1 and GIP receptors, resulting in a broader metabolic effect than GLP-1 agonist alone.

Everything included

Licensed physician consultation

Personalized compounded GLP-1/GIP treatment

Free discreet shipping

Unlimited follow-up care

Key benefits

Activates both GLP-1 and GIP receptors simultaneously

More pronounced blood sugar reduction than single-agonist therapy

Up to 20%+ body weight reduction in clinical studies

Improves triglycerides, HDL cholesterol & cardiovascular markers

Ideal for patients seeking maximum results or who've plateaued on GLP-1

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Patient satisfaction guarantee. If you're deemed ineligible after your physician consultation, you'll receive a full refund — no questions asked.

Pathway 1

GLP-1 receptor activation

This treatment binds to GLP-1 receptors to stimulate insulin secretion, suppress glucagon, and slow gastric emptying — reducing appetite and regulating blood sugar levels after meals.

Pathway 2

GIP receptor activation

Uniquely, this treatment also activates glucose-dependent insulinotropic polypeptide (GIP) receptors — enhancing fat metabolism and amplifying the body's overall insulin response beyond what GLP-1 alone can achieve.

Synergistic metabolic effect

The combined activation of both pathways creates a more pronounced metabolic response than either can produce individually — improving blood sugar control, reducing appetite, and promoting greater fat utilization simultaneously.

46 lbs

Average weight lost in landmark 72-week clinical trial

starting weight of 232 lbs

20%+

Average body weight reduction achieved

vs. 15% for semaglutide

1.7%

HbA1c reduction in diabetic patients

from clinical trials

HDL ↑

Improved cholesterol & triglyceride markers

vs. placebo

Why dual-agonist therapy outperforms single-agonist

Single GLP-1 receptor agonists like semaglutide work by mimicking one gut hormone. GLP-1/GIP treatment goes a step further — mimicking two. The addition of GIP activity means this treatment addresses fat metabolism and insulin sensitivity through an entirely separate pathway, compounding the results.

Comprehensive metabolic support

Beyond appetite suppression and blood sugar regulation, GLP-1/GIP+ Therapy influences a broader range of metabolic pathways — including glucose utilization, lipid metabolism, and energy expenditure. Patients with high blood pressure, elevated cholesterol, or type 2 diabetes frequently see meaningful improvements in all these markers alongside significant weight loss.

Sustained results without yo-yo dieting

The dual hormonal approach creates a more stable, sustained response to treatment. Patients report a fundamentally different relationship with food — not deprivation, but genuine appetite recalibration that makes healthy choices feel natural rather than forced.

When combined with a personalized low-calorie diet and regular exercise, GLP-1/GIP+ Therapy delivers measurable improvements across a wide range of health markers — not just the number on the scale.

Cardiovascular health

Reductions in blood pressure, resting heart rate, and cardiovascular risk markers have been observed with sustained therapy.

Blood sugar control

HbA1c reductions of up to 1.7% make this therapy particularly effective for overweight patients managing type 2 diabetes.

Cholesterol & lipids

Clinical studies show reductions in triglycerides and non-HDL cholesterol, alongside increases in protective HDL cholesterol.

Energy & mobility

Patients consistently report improved energy levels, reduced joint pain, and greater ease of movement as weight comes off progressively.

Beta cell function

GLP-1/GIP treatment has been shown to improve pancreatic beta cell function, supporting more natural and effective insulin regulation over time.

Mental wellbeing

Patients frequently report improved mood, self-confidence, and reduced anxiety about food as body composition and metabolic health improve.

Possible side effects

Nausea (most common, typically mild & transient)
Vomiting or diarrhea
Constipation or indigestion
Headache or fatigue (early on)
Mild injection site reactions

Monitoring & follow-up

Unlimited follow-up care included in every plan
Close glucose monitoring recommended for diabetic patients
Dose titrated gradually to minimize side effects
Physician available for adjustments at any time

Blood glucose monitoring

Due to GLP-1/GIP treatment's potent effects on insulin secretion, close monitoring of blood glucose levels is essential — particularly when used alongside other diabetes medications. Your physician will guide you through appropriate monitoring protocols as part of your personalized treatment plan.

Important contraindications

This treatment is not suitable for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2). Compounded GLP-1/GIP treatment may be prescribed off-label and is not FDA-approved for all uses. Results vary; consult your physician with any concerns before starting.

Individualized treatment plans

Before starting, your physician reviews your complete medical history, current medications, and goals. Dosing begins conservatively and is titrated upward — a protocol designed to maximize tolerability while building toward therapeutic efficacy.

Physician approval

After completing your health questionnaire, a licensed physician in your state reviews your profile. If approved, your prescription is sent to a U.S.-licensed compounding pharmacy.

Pharmacy preparation

Your personalized compounded GLP-1/GIP treatment is prepared at an licensed & regulated pharmacy. Each batch is quality-reviewed before dispatch.

Discreet delivery

Ships in unmarked, temperature-controlled packaging. Free shipping on every order — no minimum spend, no membership required.

Ongoing refills

Subsequent doses ship on a schedule aligned with your treatment protocol. Adjust timing anytime via your patient portal or by contacting support.

Delivery timeline

Most patients receive their first order within 3–7 business days of physician approval. Contact support for expedited shipping availability in your state.

Refund policy

If you're deemed ineligible for treatment after your physician consultation, a full refund is issued. Because medication is compounded specifically to your prescription, returns of dispensed medication cannot be accepted.

Patient reviews

What our patients are saying.

★★★★★

"I tried semaglutide for three months and hit a plateau. Switched to the tirzepatide protocol and the difference was immediate — I've now lost 52 lbs total. Genuinely life-changing."

Thomas R.

Verified patient · Georgia · GLP-1/GIP+ Therapy

"My doctor had me on Mounjaro® but the out-of-pocket cost was brutal. RenewlyRX's version is a fraction of the price and the support is actually better. I'm down 38 lbs in 5 months."

Michelle W.

Verified patient · Ohio · GLP-1/GIP+ Therapy

"My A1C dropped from 8.1 to 6.4 in four months alongside losing 29 lbs. My primary care physician was genuinely surprised. The whole process — from questionnaire to delivery — was seamless."

David K.

Verified patient · Arizona · GLP-1/GIP+ Therapy

Individual results vary. These testimonials reflect individual patients' experiences and are not a guarantee of results.